Esparragoza was a former police detective turned drug trafficker who served as an ad hoc negotiator and conciliator amongst drug trafficking clans. Although not as well known as his partners Ismael Zambada Garcia, alias "El Mayo," or the now imprisoned Joaquin Guzman Loera, alias "El Chapo," his history in the drug trade was just as long. He started out with the Guadalajara Cartel and may have played a role in the death of the Drug Enforcement Administration agent Enrique Camarena in 1985. He was jailed for seven years, and released in 1992. He later joined forces with the Juarez Cartel and worked under Amado Carrillo Fuentes until Carrillo’s death in 1997.
While Guzman was in jail, Esparragoza helped him maintain his business. After Guzman escaped jail in 2001, Esparragoza became part of the leadership of the Sinaloa Cartel, which includes Zambada. He was the central link in family ties between the groups, and was often appointed mediator in their conflicts. Esparragoza married Guzman’s sister-in-law, and was the godfather of Amado Carrillo Fuentes’ son and one of Ismael Zambada’s sons. One of his sons is married to the daughter of one of the Beltran Leyvas.
Esparragoza reportedly died of a heart attack on June 7, 2014 while recovering from injuries sustained during a car accident.